Disease States – Gen 3

  • Right sided infective endocarditis (RSIE), including tricuspid valve infective endocarditis (TVIE), is strongly associated with intravenous drug use (IVDU), although pacemaker leads, defibrillator leads and vascular access for dialysis are also major risk factors. Infection resulting from IVDU constitutes approximately 30-40% of all TVIE cases.1
  • Implantable cardiac electronic device (ICED) infections can be life-threatening, particularly when associated with endocardial infection, and all-cause mortality of up to 35% has been reported.2
  • Venous thromboembolism (VTE) is a common and life-threatening disease. In the U.S. and Europe, VTE-related events kill more people than AIDS, breast cancer, prostate cancer and motor vehicle crashes combined. Every year there are approximately 10 million cases of VTE worldwide.3
  • Every two seconds someone in the U.S. needs blood. It is essential for surgeries, cancer treatment, chronic illnesses, and traumatic injuries.4
  • Each year in the United States, 21 million blood components are transfused, but only 3% of age-eligible people donate blood yearly. Sometimes, this can result in supply not meeting demand.4

  1. Hussain ST, Witten J. Tricuspid Valve Endocarditis. Ann Cardiothoracic Surg, 2017; 6(3):255-261.
  2. Sandoe JA, Barlow G, Chambers JB, et al. Guidelines for the diagnosis, prevention and management of implantable cardiac electronic device infection. Report of a joint Working Party project on behalf of the British Society for Antimicrobial Chemotherapy (BSAC, host organization), British Heart Rhythm Society (BHRS), British Cardiovascular Society (BCS), British Heart Valve Society (BHVS) and British Society for Echocardiography (BSE). J Antimicrob Chemother. 2015 Feb;70(2):325-59.
  3. Know Thrombosis: Think Venous Thromboembolism. (2019). Retrieved April 29, 2019, from http://www.worldthrombosisday.org/issue/vte/
  4. Blood Needs & Blood Supply. Facts About Blood Supply In The U.S. | Red Cross Blood Services. https://www.redcrossblood.org/donate-blood/how-to-donate/how-blooddonations-help/blood-needs-blood-supply.html. Accessed July 18, 2019.